What is Lynch syndrome? On a rudimentary level, it is a rare genetic defect on the DNA that affects the proper replication of cells. Without warning, a cell will create a mutation of an original healthy cell, and will continue to excessively reproduce this mutated cell, resulting in a cancerous condition. Lynch syndrome is passed from parent to child. If the parent has it, their children have a fifty-fifty change of inheriting this mutation. Important note: Lynch does not skip generations. It is considered a sister mutation to the BRCA1 gene mutation with which Angelina Jolie was recently diagnosed. However, because Lynch syndrome affects far more systems of the body than BRCA1, it is far more heinous. Little is known about this condition. The estimation is that only about 15 percent of the doctors worldwide have even heard of it. There are several different mutations that fall under the category of Lynch. MSH6 is mine.
Here is a list of the body parts and their percentage rates above the regular population to which the MSH6 mutation predisposes an individual to cancer, some of which are transitional cell carcinomas:
Surveillance of MSH6 patients includes the following:
Prophylactic hysterectomy with bilateral salpingo oophorectomy is recommended to all women over the age of 40.